Definition Risk Factors Differential diagnosis Epidemiology - incidence of the mutation is between 1 in 10,000 and 1 in 15,000
births
- By age 35 years, 95% of individuals with FAP have polyps
Aetiology - Development of hundreds to thousands of polyps
Clinical features Pathophysiology InvestigationsManagementa) conservativeb) medical c) surgical- Prophylactic colectomy
is indicated if more than a hundred polyps are present, if there are
severely dysplastic polyps, or if multiple polyps larger than 1 cm are
present
Prognosis- Without colectomy, colon cancer is virtually inevitable
- The mean age
of colon cancer in untreated individuals is 39 years (range 34–43
years).
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