Definition - Infection of the bone or bone marrow
- Clasified based on
- Causative organism (pyogenic bacteria or mycobacteria)
- Route, duration and anatomic location of the infection
Risk Factors Differential diagnosis Epidemiology Aetiology - Infection via
- In sickel cell, the most common causative agent remains Staphylococcus aureus, but Salmonella species become proportionally more common pathogens than in healthy hosts
Clinical features Pathophysiology - Leukocytes invade
- Release enzymes which destroy the bone
- Pus entry -> imparied perfusion
- Necrosis
Investigations- Xray will reveal abcesses in bone as radiolucency
- Blood / bone culture
Managementa) conservativeb) medical c) surgicalPrognosis- May develop to chronic condition
- Chronic osteomyelitis may be due to the presence of intracellular bacteria
- Therefore resistant to antibiotics
- In infants, the infection can spread to the joint and cause arthritis
- In children, large subperiosteal abscesses can form because the periosteum is loosely attached to the surface of the bone
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