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Ulcerative colitis

Definition
Risk Factors
  • Genetics
  • Diet
  • Recent smoking cessation
    • hydrogen cyanide from cigarette smoke reacting with hydrogen sulfide to produce the nontoxic isothiocyanate?
Differential diagnosis

Epidemiology
  • 35–100 / 100,000 in the United States
  • peak incidence 15 to 25
  • bimodal distribution in age of onset, with a second peak in incidence occurring in the 6th decade of life
  • Higher incidences are seen in northern locations
Aetiology
  • Autoimmune??
Clinical features
Pathophysiology
Investigations
Management

a) conservative

b) medical
  • Aminosalicylates
  • Corticosteroids
  • Immunosuppressive drugs
  • Biological treatment
c) surgical
Prognosis

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