Definition Risk Factors - Genetics
- Diet
- Recent smoking cessation
- hydrogen cyanide from cigarette smoke reacting with hydrogen sulfide to produce the nontoxic isothiocyanate?
Differential diagnosis Epidemiology - 35–100 / 100,000 in the United States
- peak incidence 15 to 25
- bimodal distribution in age of onset, with a second peak in incidence occurring in the 6th decade of life
- Higher incidences are seen in northern locations
Aetiology Clinical features - Often mucus-like faeces/diarrhoea with blood
- Tenesmus
- Shallow, mucosal inflammation, limited to colon + rectum
- Continuous area of inflammation
- Non-peri-intestinal crypt granulomas not seen
- Extra-intestinal features:
Pathophysiology InvestigationsManagementa) conservativeb) medical - Aminosalicylates
- Corticosteroids
- Immunosuppressive drugs
- Biological treatment
c) surgicalPrognosis |
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