Class- Benzisoxazole derivative atypical antipsychotic
Indications
Administration/AbsorptionDosage
DistributionMechanism- Dopamine normaliser
- Stimulates if levels low
- Inhibits if levels high
- Selective monoaminergic antagonist with high affinity for:
- Serotonin
Type 2 (5HT2)
- Dopamine Type 2 (D2)
- 1 and 2 adrenergic
- H1
histaminergic
- Aripiprazole's antipsychotic activity is likely due to a combination of
antagonism at:
- D2 receptors in the mesolimbic pathway
- 5HT2A receptors
in the frontal cortex
- Antagonism at D2 receptors relieves positive
symptoms while antagonism at 5HT2A receptors relieves negative symptoms
of schizophrenia
Excretion- Hepatic metabolism
- Urine / faeces
- Halflife 75-146 hours
Side effects- akathisia
- headache
- agitation
- anxiety
- unusual tiredness or weakness
- nausea and vomiting
- an uncomfortable feeling in the stomach
- constipation
- increased production of saliva
- light-headedness
- insomnia
- sleepiness
- shaking
- blurred vision
- sexual dysfunction
Interactions
Contraindications
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