Indications
- Headache
- Pain
- Prevention of heart attacks and strokes
- Coronary and carotid arteries, bypasses and stents
Dosage
Administration/AbsorptionDistribution- 50–80% of salicylate in the blood is bound by protein
Mechanism- Irreversible inactivation of the cyclooxygenase (PTGS - prostaglandin-endoperoxide synthase) enzyme
- acts as an acetylating agent where an acetyl group is covalently attached to a serine residue in the active site of the PTGS enzyme
- Irreversibly blocks the formation of thromboxane A2 in platelets, producing an inhibitory effect on platelet aggregation
- 40 mg of aspirin a day is able to inhibit a large proportion of maximum thromboxane A2 release provoked acutely, with the prostaglandin I2 synthesis being little affected
ExcretionSide effectsInteractions
Contraindications
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