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Aspirin

Indications
  • Headache
  • Pain
  • Prevention of heart attacks and strokes
  • Coronary and carotid arteries, bypasses and stents
Dosage
  • Acute MI
    • 300 mg sublingually
  • Prophylactic
    • 40-75 mg
Administration/Absorption
  • Oral
Distribution
  • 50–80% of salicylate in the blood is bound by protein
Mechanism
  • Irreversible inactivation of the cyclooxygenase (PTGS - prostaglandin-endoperoxide synthase) enzyme
    • acts as an acetylating agent where an acetyl group is covalently attached to a serine residue in the active site of the PTGS enzyme
  • Irreversibly blocks the formation of thromboxane A2 in platelets, producing an inhibitory effect on platelet aggregation
  • 40 mg of aspirin a day is able to inhibit a large proportion of maximum thromboxane A2 release provoked acutely, with the prostaglandin I2 synthesis being little affected
Excretion

Side effects
  • Reye's syndrome
  • GI bleeds
Interactions

Contraindications

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