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Benzylpenicillin

AKA penicillin G

Indications
Administration/Absorption
Dosage

Distribution

Mechanism
  • Inhibits the formation of peptidoglycan cross-links in the bacterial cell wall
    • The β-lactam moiety (functional group) of penicillin binds to the enzyme (DD-transpeptidase) that links the peptidoglycan molecules in bacteria.
    • The enzymes that hydrolyze the peptidoglycan cross-links continue to function, which weakens the cell wall of the bacterium
    • In addition, the build-up of peptidoglycan precursors triggers the activation of bacterial cell wall hydrolases and autolysins, which further digest the bacteria's existing peptidoglycan
  • Shows a synergistic effect with aminoglycosides
    • inhibition of peptidoglycan synthesis allows aminoglycosides to penetrate the bacterial cell wall more easily, allowing its disruption of bacterial protein synthesis within the cell
    • This results in a lowered MBC for susceptible organisms.
Excretion

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