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Chlortalidone

Indications
Administration/Absorption

Distribution

Mechanism
  • thiazide-like diuretic
    • acts similarly to the thiazides but does not contain the benzothiadiazine molecular structure
  • Increases the excretion of sodium, chloride, and water into the renal lumen by inhibiting sodium ion transport across the renal tubular epithelium.
  • Primary site of action is in the cortical diluting segment of the ascending limb of the loop of Henle.
  • Also decreasea the glomerular filtration rate
  • By increasing the delivery of sodium to the distal renal tubule, chlorthalidone indirectly increases potassium excretion via the sodium-potassium exchange mechanism
Excretion


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