Decamethonium

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Indications

Administration/Absorption

Distribution

Mechanism

depolarizing muscle relaxant
partial agonist of the nicotinic acetylcholine receptor
In the motor endplate, it causes depolarization, preventing further effects to the normal release of acetylcholine from thepresynaptic terminal

In the process of binding, decamethonium actually activates (depolarizes) the motor endplate

but since the decamethonium itself is not degraded, the membrane remains depolarized and unresponsive to normal acetylcholine release.

Excretion

Comments

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