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Dobutamine

Indications
Administration/Absorption
  • IV infusion
Distribution

Dosage

Mechanism
  • Direct-acting inotropic agent whose primary activity results from stimulation of the beta-adrenoceptors of the heart
    • Produces comparatively mild chronotropic, hypertensive, arrhythmogenic, and vasodilative effects
    • Does not cause the release of endogenous norepinephrine, as does dopamine
  • Primary activity results from stimulation of the β1-adrenoceptors of the heart, increasing contractility and cardiac output. 
  • Since it does not act on dopamine receptors to induce the release of norepinephrine (another α1 agonist), dobutamine is less prone to induce hypertension than is dopamine.
  • Predominantly a β1-adrenergic agonist, with weak β2 activity, and α1 selective activity
    • used clinically in cases of cardiogenic shock for its β1 inotropic effect in increasing heart contractility and cardiac output. 
  • Administered as a racemic mixture consisting of both (+) and (−) isomers
    • the (+) isomer is a potent β1 agonist and α1 antagonist
    • the (−) isomer is an α1agonist.[4] 
    • (+)-Dobutamine also has mild β2 agonist activity, which makes it useful as a vasodilator.[5
Excretion
  • Half life 2 minutes
  • In human urine, the major excretion products are the conjugates of dobutamine and 3-O-methyl dobutamine
Side effects
  • Increased risk of arrhythmia, including fatal arrhythmias
  • Hypertension, angina, arrhythmia, and tachycardia
  • Used with caution in atrial fibrillation as it has the effect of increasing the atriovenrticular (AV) conduction
Interactions

Contraindications

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