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Donepezil

Class
Indications
Administration/Absorption
  • Orally disintegrating tablet
  • Relative oral bioavailability of 100%
  • Reaches peak plasma concentrations in 3 to 4 hours.
Dosage

Distribution

Mechanism
  • Enhances cholinergic function in the cerebral cortex, nucleus basalis, and hippocampus
  • This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase.
Excretion
  • Excreted in the urine intact
  • Extensively metabolized to four major metabolites, two of which are known to be active,
Side effects
Interactions
  • Alcohol
Contraindications

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