Indications
Administration/AbsorptionDistributionMechanism- Localises at the brush border of the small intestine
- inhibits the absorption of cholesterol from the intestine
- Binds to a critical mediator of cholesterol absorption:
- Also, decreased cholesterol absorption leads to an upregulation of LDL-receptors on the surface of cells
- => increased LDL-cholesterol uptake into cells
- => decreased plasma levels of LDL
Excretion |
|
