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Fenofibrate

Indications
Administration/Absorption

Distribution

Mechanism
  • fibrate class
  • Effects via activation of Peroxisome Proliferator Activated Receptor type alpha (PPARα)
    • Increases the lipolysis and elimination of atherogenic triglyceride-rich particles from plasma by 
      • activating lipoprotein lipase 
      • reducing production of apoprotein CIII. 
    • Also induces an increase in the synthesis of apoproteins AI and AII
      • leads to a reduction in very low - and low density fractions (VLDL and LDL) containing apoprotein B 
      • and an increase in the high density lipoprotein fraction (HDL) containing apoprotein AI and AII. 
  • Increases LDL clearance and reduces small and dense LDL
Excretion


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