Indications
Administration/AbsorptionDistributionMechanism- fibrate class
- Effects via activation of Peroxisome Proliferator Activated Receptor type alpha (PPARα)
- Increases the lipolysis and elimination of atherogenic triglyceride-rich particles from plasma by
- activating lipoprotein lipase
- reducing production of apoprotein CIII.
- Also induces an increase in the synthesis of apoproteins AI and AII
- leads to a reduction in very low - and low density fractions (VLDL and LDL) containing apoprotein B
- and an increase in the high density lipoprotein fraction (HDL) containing apoprotein AI and AII.
- Increases LDL clearance and reduces small and dense LDL
Excretion |
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