Indications
- septicaemia and neonatal sepsis
- meningitis and other CNS infections
- biliary-tract infection
- acute pyelonephritis or prostatitis
- endocarditis
- pneumonia in hospital patients
- adjunct in listerial
meningitis
Administration/AbsorptionDosage
Distribution- binds
avidly to certain tissues.
Mechanism- vs Gram-negative organisms
- Several potential antibiotic mechanisms, some as protein synthesis inhibitors, although their exact mechanism of action is not fully known:
- Interfere with the proofreading process, causing increased rate of error in synthesis with premature termination.[3]
- Evidence of inhibition of ribosomal translocation where the peptidyl-tRNA moves from the A-site to the P-site.[3]
- Can also disrupt the integrity of bacterial cell membrane.[4]
- Bind to the bacterial 30S ribosomal subunit[5][6] (some work by binding to the 50S subunit[7])
Excretion- Completely eliminated unchanged in the urine
Side effects- nephrotoxicity
- gentamicin toxicity:
- Balance difficulty
- Bouncing, unsteady vision
- Ringing in the ears
- Difficulty multi-tasking, particularly when standing
Interactions
Contraindications
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