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Gentamicin

Indications
  • septicaemia and neonatal sepsis
  • meningitis and other CNS infections
  • biliary-tract infection
  • acute pyelonephritis or prostatitis
  • endocarditis
  • pneumonia in hospital patients
  • adjunct in listerial meningitis
Administration/Absorption
Dosage

Distribution
  • binds avidly to certain tissues.
Mechanism
  • vs Gram-negative organisms
  • Several potential antibiotic mechanisms, some as protein synthesis inhibitors, although their exact mechanism of action is not fully known:
    • Interfere with the proofreading process, causing increased rate of error in synthesis with premature termination.[3]
    • Evidence of inhibition of ribosomal translocation where the peptidyl-tRNA moves from the A-site to the P-site.[3]
    • Can also disrupt the integrity of bacterial cell membrane.[4]
  • Bind to the bacterial 30S ribosomal subunit[5][6] (some work by binding to the 50S subunit[7])
Excretion
  • Completely eliminated unchanged in the urine
Side effects
  • nephrotoxicity
  • gentamicin toxicity:
    • Balance difficulty
    • Bouncing, unsteady vision
    • Ringing in the ears
    • Difficulty multi-tasking, particularly when standing
Interactions

Contraindications
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