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Haloperidol

Class
Indications
  • Schizophrenia
  • Acute psychotic states and delirium
    • Schizoaffective disorder
    • Delusional disorders
  • Ballism
  • Tourette syndrome (a drug of choice) 
  • Occasionally as adjunctive therapy in mental retardation and the chorea of huntington disease
  • Intractable hiccups
  • ADHD
  • Severe nausea and vomiting 
Administration/Absorption
  • Oral
  • IM
  • IV
Dosage
  • Plasma levels of 4 to 25 micrograms per liter are required for therapeutic action.

Distribution
  • 92% protein bound
Mechanism
Excretion
  • Plasma concentrations of haloperidol decanoate reach a peak at about 6 days after the injection, falling thereafter, with an approx. half-life of 3 weeks
  • Liver metabolism
Side effects
Interactions

Contraindications
  • Absolute
    • Preexisting coma, acute stroke
    • Severe intoxication with alcohol or other central depressant drugs
    • Known allergy against haloperidol or other butyrophenones or other drug ingredients
    • Known heart disease; when combined will tend towards cardiac arrest
  • Special caution needed
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