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Indometacin

Indications
Administration/Absorption

Dosage

Distribution

Mechanism
Excretion

Side effects
Interactions

Contraindications
  • concurrent peptic ulcer, or history of ulcer disease
  • allergy to indomethacin, aspirin, or other NSAIDs
  • patients with nasal polyps reacting with an angioedema to other NSAIDs
  • children under 2 years of age (with the exception of neonates with patent ductus arteriosus)
  • severe pre-existing renal and liver damage
  • caution: pre-existing bone marrow damage (frequent blood cell counts are indicated)
  • caution: bleeding tendencies of unknown origin (indomethacin inhibits platelet aggregation)
  • caution: Parkinson's disease[citation needed], epilepsy, psychotic disorders (indomethacin may worsen these conditions)
  • concurrent with potassium sparing diuretics
  • patients who have a patent ductus arteriosus dependent heart defect (such as Transposition of the great vessels)
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