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Leflunomide

Class
Indications
Administration/Absorption

Dosage

Distribution

Mechanism
  • Inhibits dihydroorotate dehydrogenase 
    • Enzyme involved in de novo pyrimidine synthesis
  • Most cells can bypass this blockage
    • Except T cells
    • => anti-inflammatory effect
Excretion
  • Long half-life (2 weeks)
  • Up to 2 years to eliminate completely
Side effects
Interactions
Contraindications

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