Lidocaine

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Class

Indications

Administration/Absorption

Injected local anesthetic (sometimes combined with epinephrine to reduce bleeding)
IV
Topical gel/patch

Dosage

Distribution

Mechanism

alters signal conduction in neurons by blocking the fast voltage gated sodium (Na⁺) channels in the neuronal cell membrane

Excretion

95% metabolized (dealkylated) in the liver by CYP3A4 to the pharmacologically-active metabolites monoethylglycinexylidide (MEGX) and then subsequently to the inactive glycine xylidide
elimination half-life of lidocaine is approximately 90–120 minutes in most patients

Side effects

Interactions

Contraindications

Comments

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