Drugs‎ > ‎

Losartan

Indications
Administration/Absorption
  • Well absorbed following oral administration
  • Undergoes significant first-pass metabolism to produce 5-carboxylic acid metabolite, designated as EXP3174.
  • This metabolite is a long-acting (6 to 8 hr), noncompetitive antagonist at the AT1 receptor and contributes to the pharmacological effects of Losartan.
  • This metabolite is 10-40 times more potent in blocking AT1 receptors than the original Losartan.
Distribution
Mechanism
Excretion


Comments