Indications
Administration/Absorption- Well absorbed following oral administration
- Undergoes significant
first-pass metabolism to produce 5-carboxylic acid metabolite,
designated as EXP3174.
- This metabolite is a long-acting (6 to 8 hr),
noncompetitive antagonist at the AT1 receptor and contributes to the
pharmacological effects of Losartan.
- This metabolite is 10-40 times
more potent in blocking AT1 receptors than the original Losartan.
DistributionMechanismExcretion |
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