ClassIndications
Administration/Absorption
- Oral
- Poorly absorbed (approximately 5 to 10%) from gastrointestinal tract
- Fatty food increases absorption
Dosage
- Pinworms: 100 mg once
- Whipworm, common roundworm and hookworm: 100 mg BD for 3 days
Distribution
Mechanism
- Selectively inhibits the synthesis of microtubules in parasitic worms
- => destroys extant cytoplasmic microtubes in their intestinal cells
- Thereby blocks the uptake of glucose and other nutrients
- Results in the gradual immobilization and eventual death of the helminths
Excretion
- Primarily hepatic metabolism
- Half life 2.5 to 5.5 hours
Side effects
- Transient abdominal pain, diarrhea, slight headache, fever, dizziness, exanthema, urticaria and angioedema
Interactions
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