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Mebendazole

Class
Indications
Administration/Absorption
  • Oral
  • Poorly absorbed (approximately 5 to 10%) from gastrointestinal tract
    • Fatty food increases absorption
Dosage
  • Pinworms: 100 mg once
  • Whipworm, common roundworm and hookworm: 100 mg BD for 3 days
Distribution
  • 90-95% protein bound
Mechanism
  • Selectively inhibits the synthesis of microtubules in parasitic worms
    • => destroys extant cytoplasmic microtubes in their intestinal cells
  • Thereby blocks the uptake of glucose and other nutrients
  • Results in the gradual immobilization and eventual death of the helminths
Excretion
  • Primarily hepatic metabolism
  • Half life 2.5 to 5.5 hours
Side effects
  • Transient abdominal pain, diarrhea, slight headache, fever, dizziness, exanthema, urticaria and angioedema
Interactions
Contraindications
  • Pregnancy
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