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Olanzapine

Class
Indications
  • Acute and maintenance treatment of schizophrenia and related psychotic disorders
  • Acute treatment of manic or mixed episodes of bipolar 1 disorder
  • Psychotic symptoms in dementia
  • Intramuscular olanzapine is indicated for the rapid control of agitated patients
Administration/Absorption
  • Oral
    • 40% of the dose metabolized before reaching the systemic circulation
  • IM
Dosage

Distribution
  • 93% protein bound
  • VOD 1000 L
Mechanism
  • Combination of antagonism at:
    • D2 receptors in the mesolimbic pathway
      • Relieves positive symptoms
    • 5HT2A receptors in the frontal cortex
      • Relieves negative symptoms
Excretion
  • Metabolized by the cytochrome P450 system isoenzymes 1A2 and 2D6
  • Only 7% excreted unchanged in urine
  • Half life 21 - 54 hr
Side effects
Interactions

Contraindications

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