Kieran's Medical Notes
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>
Omeprazole
Class
proton pump inhibitor
Indications
dyspepsia
peptic ulcer disease
(PUD)
gastroesophageal reflux disease
(GORD/GERD)
l
aryngopharyngeal reflux
(LPR)
Zollinger-Ellison syndrome
Administration/Absorption
Oral
IV
Dosage
Distribution
Mechanism
reacts with a cysteine group in
H
+
/K
+
ATPase
, thereby inhibiting the ability of the
parietal cells
to produce
gastric acid
omeprazole undergoes a
chiral shift
in vivo
which converts the inactive R-enantiomer to the active S-enantiomer
doubles the concentration of the active form
accomplished by the
CYP2C19
isozyme
of
cytochrome P450
not found equally in all human populations
Excretion
Side effects
headache
diarrhea
abdominal pain
nausea
dizziness
trouble awakening and sleep deprivation
hip fractures,
[
9
]
[
10
]
[
11
]
Clostridium difficile
-associated diarrhea
bone rebuild interference and B12 vitamin reduction.
[
15
]
tubulointerstitial nephritis
[
16
]
[
17
]
Link to gastric cancer?
Interactions
competitive inhibitor
of the enzymes
CYP2C19
and
CYP2C9
Contraindications
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