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Procyclidine

Class
Indications
Administration/Absorption

Dosage

Distribution
  • Approximately 100% bound to albumin
Mechanism
  • Crosses blood-brain barrier
  • Has an atropine-like action on parasympathetic-innervated peripheral structures including smooth muscle
  • Antispasmodic effects are thought to be related to the blockage of central cholinergic receptors M1, M2 and M4
    • Balances cholinergic and dopaminergic activity in the basal ganglia
Excretion

Side effects
  • Exerts an antispasmodic effect on smooth muscle
    • May produce mydriasis and reduction in salivation
Interactions

Contraindications

Comments