Sulphasalazine - Kieran's Medical Notes

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Sulphasalazine

Class

Mesalazine derivative anti-inflammatory agent

Indications

inflammatory bowel disease
rheumatoid arthritis
enthesitis related arthritis like juvenile spondyloarthropathie

Administration/Absorption

Poorly absorbed from the gut

Most effects are within the gut?

Affinity for connective tissue and accumulates in joint spaces

Dosage

Distribution

Mechanism

Metabolised to:

sulfapyridine which gives rise to side-effects
5-aminosalicylic acid (5-ASA) which gives therapeutic effects

Reduces the synthesis of eicosanoids and inflammatory cytokines
No immunosuppressant action
Systemic decrease in IL-1, TNF-alpha (and IL-6)

Excretion

Side effects

Interactions

Contraindications

Comments