Kieran's Medical Notes
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Sulphasalazine
Class
Mesalazine
derivative anti-inflammatory agent
Indications
inflammatory bowel disease
rheumatoid arthritis
enthesitis related arthritis like juvenile spondyloarthropathie
Administration/Absorption
Poorly absorbed from the gut
Most effects are within the gut?
Affinity for connective tissue and accumulates in joint spaces
Dosage
Distribution
Mechanism
Metabolised to:
sulfapyridine
which gives rise to side-effects
5-aminosalicylic acid
(5-ASA) which gives therapeutic effects
Reduces the synthesis of
eicosanoids
and inflammatory
cytokines
No
immunosuppressant
action
Systemic decrease in IL-1,
TNF-alpha (and IL-6)
Excretion
Side effects
agranulocytosis
hypospermia
Immune
thrombocytopenia
Interactions
Contraindications
Comments