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12.09.28 Stuff

Capillary leak syndrome
  • Self-reversing episodes during which the endothelial cells which line the capillaries are thought to separate for a few days
  • Possible prodromal symptoms:
    • Runny nose and/or other flu-like symptoms
    • Gastro-intestinal disorders (diarrhea or vomiting)
    • General weakness or pain in limbs
  • Signs:
    • hemoconcentration
    • hypotension
    • hypoalbuminemia
    • partial or generalized oedema
  • Phases:
    • Capillary leak phase
      • Lasts from 1 to 3 days
      • Up to 70% of total plasma volume may invade cavities in the trunk and extremities
    • Recruitment phase
      • Reabsorption of the initially extravasated fluid
      • Usually lasts just as long as the leak phase
      • Can => polyuria, PE
  • Prevention
    • Beta agonists such as theophylline, terbutaline and montelukast sodium
    • IVIG

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