Capillary leak syndrome- Self-reversing episodes during which the endothelial cells which line the capillaries are thought to separate for a few days
- Possible prodromal symptoms:
- Runny nose and/or other flu-like symptoms
- Gastro-intestinal
disorders (diarrhea or vomiting)
- General weakness or pain in limbs
- Signs:
- hemoconcentration
- hypotension
- hypoalbuminemia
- partial or generalized oedema
- Phases:
- Capillary leak phase
- Lasts from 1 to 3 days
- Up to 70% of total plasma volume may invade cavities in the trunk and extremities
- Recruitment phase
- Reabsorption of the initially extravasated fluid
- Usually lasts just as long as the leak phase
- Can => polyuria, PE
- Prevention
- Beta agonists such as theophylline, terbutaline and montelukast sodium
- IVIG
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