Thrombus vs clot- Thrombus
- Within a vessel
- Contains platelets
- Clot
- Outside the circulation
- No platelets
Virchow
- Endothelial injury
- Abnormal flow
- Hypercoagulability
- Polycythaemia
- Coagulopathy
- Congenital
- Acquired (pregnancy, cancer)
Atheroma outcomes
- Occlusion/stenosis
- Rupture
- Aneurysm
Perforated viscus
- Peptic ulcer
- Appendix
- Sigmoid colon
- Diverticular disease
- Tumour
Diverticular disease
- Presents very similarly to CRC!
- Bleeding
- Obstruction
- Change in bowel habits
- Infection / abscess
- Strictures
Complications of MI
- Arrhythmias / Aneurysm
- Bradycardia / ↓BP
- Cardiac failure / cardiac tamponade
- Dresslers / Death
- Embolism / Extra (VSD, pap muscle rupture)
Notes- Plasminogen => Plasmin => Clot breakdown
- Primary cause of clots
- Atheroma in arteries, Clots in veins
- Ischaemia is DYSFUNCTION due to reduced blood flow
- Hartman's is an EMERGENCY procedure
- Peritonism/rupture
- No primary anastamosis
- Ventricular aneurysms DON'T rupture
- Danger time post-MI is 2-3 days
- Myocytes are broken down but scar has not yet formed
- => VSD, aneurysm
- MI => Acute inflammation => Neutrophils
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