• Thrombus
• Within a vessel
• Contains platelets
• Clot
• Outside the circulation
• No platelets

Virchow

• Endothelial injury
• Atheroma
• Vasculitis
• Trauma
• Abnormal flow
• Turbulence
• Stasis
• Hypercoagulability
• Polycythaemia
• Coagulopathy
• Congenital
• Acquired (pregnancy, cancer)
  

Atheroma outcomes

• Occlusion/stenosis
• Rupture
• Occlusion
• Embolus
• Aneurysm
• Rupture
• Thromboembolus

Perforated viscus

• Peptic ulcer
• Appendix
• Sigmoid colon
• Diverticular disease
• Tumour

Diverticular disease

• Presents very similarly to CRC!
• Bleeding
• Obstruction
• Change in bowel habits
• Infection / abscess
• Strictures

Complications of MI

• Arrhythmias / Aneurysm
• Bradycardia / ↓BP
• Cardiac failure / cardiac tamponade
• Dresslers / Death
• Embolism / Extra (VSD, pap muscle rupture)

• Plasminogen => Plasmin => Clot breakdown
• Primary cause of clots
• Atheroma in arteries, Clots in veins
• Ischaemia is DYSFUNCTION due to reduced blood flow
• Hartman's is an EMERGENCY procedure
• Peritonism/rupture
• No primary anastamosis
• Ventricular aneurysms DON'T rupture
• Cause thrombus instead
• Danger time post-MI is 2-3 days
• Myocytes are broken down but scar has not yet formed
• => VSD, aneurysm
• MI => Acute inflammation => Neutrophils