Alteplase

Indications

• • Thrombolysis

    • myocardial infarction with ST-elevation (STEMI)

    • acute ischemic stroke (AIS)

    • acute massive pulmonary embolism

    • central venous access devices (CVAD)

Administration/Absorption

Distribution

Mechanism

• • Recombinant tissue plaminogen activator

  • catalyzes the conversion of plasminogen into plasmin by cleaving the single-chain plasminogen into two chains

    • These two chains are linked by a disulfide bond and the resulting molecule is called plasmin.

Excretion

Side effects