Procyclidine

Class

• Antimuscarinic

Indications

• • Drug-induced parkinsonism, akathisia and acute dystonia

• Parkinson disease

  • Idiopathic or secondary dystonia

Administration/Absorption

Dosage

Distribution

• • Approximately 100% bound to albumin

Mechanism

• • Crosses blood-brain barrier

  • Has an atropine-like action on parasympathetic-innervated peripheral structures including smooth muscle

  • Antispasmodic effects are thought to be related to the blockage of central cholinergic receptors M1, M2 and M4

    • Balances cholinergic and dopaminergic activity in the basal ganglia

Excretion

Side effects

• • Exerts an antispasmodic effect on smooth muscle

    • May produce mydriasis and reduction in salivation

Interactions

Contraindications