Carbachol

Indications

• glaucoma

Administration/Absorption

• topical ocular or through intraocular injection

• two to 5 minute onset of action and its duration of action is 4 to 8 hours with topical administration and 24 hours for intraocular administration

Distribution

Mechanism

• cholinergic agonist

  • Binds and activates the acetylcholine receptor

• parasympathomimetic that stimulates both muscarinic and nicotinic receptors

  • In topical ocular and intraocular administration its principal effects are miosis and increased aqueous humour outflow.

Excretion

• not easily metabolized by cholinesterase