P year‎ > ‎Neurology‎ > ‎

12.11.16 Final bits

Chronic cerebrospinal venous insufficiency
  • Compromised flow of blood in the veins draining the CNS
    • Hypothesised to play a role in the cause or evolution MS
    • Malformed blood vessels cause increased deposition of iron in the brain, which in turn triggers autoimmunity and degeneration of the nerve's myelin sheath
  • Proposed procedure (Zamboni liberation procedure or Zamboni liberation therapy) involving angioplasty (or stenting) of certain veins in an attempt to improve blood flow
    • No firm evidence this exists, or that the procedure does more harm than good


Cerebellar haemangioblastoma

  • CNS tumors that originate from the vascular system usually during middle-age
  • Sometimes may occur in other sites such as the spinal cord and retina
  • May be associated with other diseases such as polycythemia, pancreatic cysts and Von Hippel-Lindau syndrome
  • Most commonly composed of stromal cells in small blood vessels
  • Classed as grade one tumors under the World Health Organisation's classification system

DaT scan
  • DaTSCAN is a solution of ioflupane (123I) for injection
    • Ioflupane has a high binding affinity for presynaptic dopamine transporters (DAT) in the brains of mammals, in particular the striatal region of the brain
    • Use gamma camera to image transporters
  • Indicated in cases of tremor of unknown origin
  • Not useful for diagnosing Parkinsons by itself
    • c.f. Multiple system atrophy (MSA) + progressive supranuclear palsy (PSP), which also involve loss of DaT
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