Tends to present initially in the teens and twenties, with another peak incidence in the fifties to seventies
Prevalence ( Northern Europe): 27–48 per 100,000
Higher incidence in western industrialized nations compared to other parts of the world
Males and females are equally affected
Smokers are two times more likely to develop Crohn's disease than nonsmokers.
autoimmune disease of the gastrointestinal tract
Increasing body of evidence in favor of the hypothesis that Crohn's disease results from an impaired innate immunity
Transmural pattern of inflammation
Ulceration is an outcome seen in highly active disease
Usually an abrupt transition between unaffected tissue and the ulcer.
Granulomas are found in 50% of cases and are most specific for Crohn's disease
Do not show "caseation"
used when partial or a full blockage of the intestine occurs