Cholestyramine

Indications

• hypercholesterolemia

• dyslipidemia

Administration/Absorption

Distribution

Mechanism

• strong ion exchange resin

• binds bile in the gastrointestinal tract to prevent its reabsorption

• forms insoluble complexes with bile acids in the intestine, which are then excreted in feces

• Plasma cholesterol is converted to bile acid to normalize bile acid levels.

• This conversion of cholesterol into bile acids lowers plasma cholesterol concentrations

Excretion