Cholestyramine

Indications

Administration/Absorption

Distribution

Mechanism

  • strong ion exchange resin

  • binds bile in the gastrointestinal tract to prevent its reabsorption

  • forms insoluble complexes with bile acids in the intestine, which are then excreted in feces

  • Plasma cholesterol is converted to bile acid to normalize bile acid levels.

  • This conversion of cholesterol into bile acids lowers plasma cholesterol concentrations

Excretion