Formerly used in anesthesia to induce paralysis.
partial agonist of the nicotinic acetylcholine receptor
In the motor endplate, it causes depolarization, preventing further effects to the normal release of acetylcholine from thepresynaptic terminal
therefore preventing the neural stimulus from affecting the muscle.
In the process of binding, decamethonium actually activates (depolarizes) the motor endplate
but since the decamethonium itself is not degraded, the membrane remains depolarized and unresponsive to normal acetylcholine release.