Eplerenone

Indications

• • management of chronic heart failure

  • reduction of risk of cardiovascular death in patients with heart failure and left ventricular dysfunction

    • within 3–14 days of an acute myocardial infarction

Administration/Absorption

Dosage

Distribution

Mechanism

• aldosterone antagonist

Excretion

• • primarily metabolised by the cytochrome P450 enzyme CYP3A4

Side effects

• hyperkalaemia

• hypotension

  • dizziness

  • altered renal function

  • increased creatinine concentration

Interactions

Contraindications

• hyperkalaemia

  • severe renal impairment (creatinine Cl less than 30 ml/min)

  • severe hepatic impairment