Prednisolone

Indications

Administration/Absorption

Distribution

Mechanism

    • corticosteroid drug

    • irreversibly binds with glucocorticoid receptors (GR) alpha and beta

      • AlphaGR and BetaGR are found in virtually all tissues with variable numbers between 3000 - 10000 per cell depending on the tissue involved

    • systemic suppression of inflammation and immune response

Excretion

    • half life 2-3 hours

    • renal excretion

Side effects