Indometacin

Indications

Administration/Absorption

Dosage

Distribution

Mechanism

Excretion

Side effects

Interactions

Contraindications

    • concurrent peptic ulcer, or history of ulcer disease

    • allergy to indomethacin, aspirin, or other NSAIDs

    • patients with nasal polyps reacting with an angioedema to other NSAIDs

    • children under 2 years of age (with the exception of neonates with patent ductus arteriosus)

    • severe pre-existing renal and liver damage

    • caution: pre-existing bone marrow damage (frequent blood cell counts are indicated)

    • caution: bleeding tendencies of unknown origin (indomethacin inhibits platelet aggregation)

    • caution: Parkinson's disease[citation needed], epilepsy, psychotic disorders (indomethacin may worsen these conditions)

    • concurrent with potassium sparing diuretics

    • patients who have a patent ductus arteriosus dependent heart defect (such as Transposition of the great vessels)