Leflunomide

Class

Indications

Administration/Absorption

Dosage

Distribution

Mechanism

  • Inhibits dihydroorotate dehydrogenase

    • Enzyme involved in de novo pyrimidine synthesis

  • Most cells can bypass this blockage

    • Except T cells

    • => anti-inflammatory effect

Excretion

    • Long half-life (2 weeks)

    • Up to 2 years to eliminate completely

Side effects

Interactions

Contraindications