Destroys both normal and malignant B cells that have CD20 on their surfaces
widely expressed on B cells, from early pre-B cells to later in differentiation
absent on terminally differentiated plasma cells
General regulatory effect on the cell cycle.
Increases MHC II and adhesion molecules LFA-1 and LFA-3 (lymphocyte function-associated antigen).
Elicits shedding of CD23.
Downregulates the B cell receptor.
Induces apoptosis of CD20+ cells.
Affects and entirely depletes peripheral B cells
Only depletes 60-70% of B cells within in the lymphatics system
Rarely affects those present in the bone marrow.
Severe infusion reactions