Carbimazole

Class

• • thioamide class thyroid peroxidase inhibitor

Indications

• hyperthyroidism

Administration/Absorption

• • Oral

Dosage

Distribution

Mechanism

• pro-drug is converted to the active form, methimazole

• Methimazole prevents the thyroid peroxidase enzyme from coupling and iodinating the tyrosine residues on thyroglobulin

  • hence reducing the production of the thyroid hormones T3 and T4 (thyroxine)

Excretion

Side effects

Interactions

Contraindications