Bethanechol

Indications

• Urinary retention resulting from general anesthetic or diabetic neuropathy of the bladder

• Gastrointestinal atony

Administration/Absorption

• orally or subcutaneously

Distribution

Mechanism

• Parasympathomimetic choline ester

• selectively stimulates muscarinic receptors without any effect on nicotinic receptors

• Unlike acetylcholine, bethanechol is not hydrolyzed by cholinesterase and will therefore have a long duration of action

• Bethanechol does not involve the action of the muscarinic M3 receptor subtype in-vitro

Excretion