Amiloride

Class

• Potassium-sparing diuretic

Indications

• • hypertension

  • congestive heart failure.

Administration/Absorption

Dosage

Distribution

Mechanism

• • Directly blocks the epithelial sodium channel (ENaC) thereby inhibiting sodium reabsorption in the late distal convoluted tubules, connecting tubules, and collecting ducts

  • Promotes the loss of sodium and water from the body, but without depleting potassium

Excretion

Side effects

Interactions

Contraindications