Bendroflumethiazide

Indications

• hypertension

  • mild heart failure

  • familial hyperkalemia

  • edema

  • urinary tract disorders

Dosage

Administration/Absorption

• • Absorbed relatively rapidly after oral administration

Distribution

• • 96% protein bound

Mechanism

• • Thiazide diuretic

    • Inhibits Na⁺/Cl^- reabsorption at the beginning of the distal convoluted tubule (DCT) by blocking the thiazide-sensitive Na-Cl cotransporter

      • => Excretion of sodium, chloride and water

    • This results in an increase in potassium excretion via the sodium-potassium exchange mechanism

  • Vasodilation

    • Mechanism unclear

      • Activating calcium-activated potassium channels (large conductance) in vascular smooth muscles?

      • Inhibiting various carbonic anhydrases in vascular tissue?

  • Thiazides also cause an increase in serum uric acid

Excretion

• • Half life 8.5 hrs

Side effects

• • Common adverse effects

  • postural hypotension

    • hyponatraemia, hypokalaemia, hypercalcaemia

  • gout

    • impaired glucose tolerance

  • impotence

  • Rare adverse effects

  • thrombocytopenia

  • agranulocytosis

  • photosensitivity rash

  • pancreatitis

Interactions

Contraindications