Reduction of cholesterol levels in patients at risk of cardiovascular disease
Effects via activation of Peroxisome Proliferator Activated Receptor type alpha (PPARα)
Increases the lipolysis and elimination of atherogenic triglyceride-rich particles from plasma by
activating lipoprotein lipase
reducing production of apoprotein CIII.
Also induces an increase in the synthesis of apoproteins AI and AII
leads to a reduction in very low - and low density fractions (VLDL and LDL) containing apoprotein B
and an increase in the high density lipoprotein fraction (HDL) containing apoprotein AI and AII.
Increases LDL clearance and reduces small and dense LDL