Fenofibrate

Indications

Administration/Absorption

Distribution

Mechanism

  • fibrate class

  • Effects via activation of Peroxisome Proliferator Activated Receptor type alpha (PPARα)

    • Increases the lipolysis and elimination of atherogenic triglyceride-rich particles from plasma by

      • activating lipoprotein lipase

      • reducing production of apoprotein CIII.

    • Also induces an increase in the synthesis of apoproteins AI and AII

      • leads to a reduction in very low - and low density fractions (VLDL and LDL) containing apoprotein B

      • and an increase in the high density lipoprotein fraction (HDL) containing apoprotein AI and AII.

  • Increases LDL clearance and reduces small and dense LDL

Excretion