Abatacept

Class

• Selective costimulation modulator inhibiting the costimulation of T cells

Indications

• Treatment of rheumatoid arthritis in the case of inadequate response to anti-TNFα therapy

• psoriasis

Administration/Absorption

Dosage

Distribution

Mechanism

• Fusion protein composed of an immunoglobulin fused to the extracellular domain of CTLA-4, which can bind B7

• Binding to the B7 protein on APCs prevents them from delivering the costimulatory signal to T cells

• Thus prevents the full activation of T cells.^[1][2]

Excretion

Side effects

Interactions

Contraindications