Palliative treatment of mild to moderate Alzheimer's disease
Off label for Lewy body dementia and vascular dementia
Orally disintegrating tablet
Relative oral bioavailability of 100%
Reaches peak plasma concentrations in 3 to 4 hours.
Enhances cholinergic function in the cerebral cortex, nucleus basalis, and hippocampus
This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase.
Excreted in the urine intact
Extensively metabolized to four major metabolites, two of which are known to be active,
Bradycardia, nausea, diarrhea, anorexia, abdominal pain, and vivid dreams