Donepezil

Class

Indications

Administration/Absorption

    • Orally disintegrating tablet

    • Relative oral bioavailability of 100%

    • Reaches peak plasma concentrations in 3 to 4 hours.

Dosage

Distribution

Mechanism

    • Enhances cholinergic function in the cerebral cortex, nucleus basalis, and hippocampus

    • This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase.

Excretion

    • Excreted in the urine intact

    • Extensively metabolized to four major metabolites, two of which are known to be active,

Side effects

Interactions

    • Alcohol

Contraindications