Chlortalidone

Indications

Administration/Absorption

Distribution

Mechanism

    • thiazide-like diuretic

      • acts similarly to the thiazides but does not contain the benzothiadiazine molecular structure

    • Increases the excretion of sodium, chloride, and water into the renal lumen by inhibiting sodium ion transport across the renal tubular epithelium.

    • Primary site of action is in the cortical diluting segment of the ascending limb of the loop of Henle.

    • Also decreasea the glomerular filtration rate

    • By increasing the delivery of sodium to the distal renal tubule, chlorthalidone indirectly increases potassium excretion via the sodium-potassium exchange mechanism

Excretion