Amiodarone

Indications

• antiarrhythmic agent

  • various types of tachyarrhythmias

  • both ventricular and supraventricular (atrial) arrhythmias

Administration/Absorption

Distribution

Mechanism

• class III antiarrhythmic agent

  • prolongs phase 3 of the cardiac action potential

• beta blocker-like and potassium channel blocker-like actions on the SA and AV nodes

• increases the refractory period via sodium- and potassium-channel effects

• slows intra-cardiac conduction of the cardiac action potential, via sodium-channel effects

Excretion