Benzodiazepines bind at the interface of the α and γ subunits on the GABAA receptor
The inhibitory effect of the available GABA is potentiated, leading to sedatory and anxiolytic effects.
short-acting benzodiazepine in adults with an elimination half-life of one to four hours
Midazolam is metabolised into an active metabolite alpha1-hydroxymidazolam
However, the active metabolite of midazolam is minor and contributes to only 10 percent of biological activity of midazolam.