Methotrexate

Class

Indications

Administration/Absorption

    • Oral

    • IM/IV/IT/Subcut

  • Mean oral bioavailability is 33% (13-76% range)

  • Mean intramuscular bioavailability is 76%

Dosage

Distribution

Mechanism

Excretion

Side effects

Interactions

  • Penicillins may decrease the elimination of methotrexate

Contraindications