Preventive medication for migraine
Given orally, 90–100% of Verapamil is absorbed
Due to high first-pass metabolism, bioavailability is much lower (10–35%).
It is 90% bound to plasma proteins and has a volume of distribution of 3–5 L/kg−1.
L-type calcium channel blocker
block voltage-dependent calcium channels
class 4 antiarrhythmic