Gentamicin

Indications

    • septicaemia and neonatal sepsis

    • meningitis and other CNS infections

    • biliary-tract infection

    • acute pyelonephritis or prostatitis

    • endocarditis

    • pneumonia in hospital patients

    • adjunct in listerial meningitis

Administration/Absorption

Dosage

Distribution

    • binds avidly to certain tissues.

Mechanism

Excretion

    • Completely eliminated unchanged in the urine

Side effects

  • nephrotoxicity

    • gentamicin toxicity:

      • Balance difficulty

      • Bouncing, unsteady vision

      • Ringing in the ears

      • Difficulty multi-tasking, particularly when standing

Interactions

Contraindications